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In order to formulate aqueous multivitamin solutions containing both oil-soluble (A, D, E) and water-soluble vitmains (B1, B2, B6, B12, C and niacinamide) in 1ml-dose, the effects of various additives such as cosolvents (propylene glycol, polyethylene glycol, glycerin), a sweetener (sorbitol) and a surfactant (Cremophor(R) RH40) on the solubility of oil-soluble vitamins in water were evaluated. Cremophor(R) RH40 showed the excellent capacity on the solubilization of oil-soluble vitamins, and the simultaneous addition of cosolvents and surfactant resulted in synergetic effects on the solubilization of oil-soluble vitamins. The effects of the combination of the cosolvents and sweetener on the stability of multivitamin solutions were also evaluated by determining the amount of vitmain A and B1 remained in the solutions after storing at 40oC for 9 weeks. The formulation consisting of Cremophor(R) RH40 15%, PG 20%, and sorbitol 20% resulted in the best stability of vitamin A and B1. The stability of vitamin A and B1 in this formulation was evaluated at 50, 60, and 70oC up to 40 days. The shelf-lives of vitamin A and B1 in the formulation, calculated using the Arrhenius equation, were 1,521 days and 475 days at 20oC, respectively.
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